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Biomarker Profiles in Women with PCOS and PCOS Offspring; A Pilot Study.


ABSTRACT:

Objective

To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring.

Design

Cross-sectional comparison of serum biomarkers.

Setting

University Medical Center Utrecht.

Patients

Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30).

Main outcome measure(s)

Clustering profile of adipocytokines (IL-1b, IL-6, IL-13, IL-17, IL-18, TNF-?, adiponectin, adipsin, leptin, chemerin, resistin, RBP4, DPP-IV/sCD26, CCL2/MCP-1), growth factors (PIGF, VEGF, sVEGF-R1), soluble cell adhesion molecules (sICAM-1/sCD54, sVCAM-1/sCD106), and other inflammatory related proteases (MMP-9, S100A8, Cathepsin S). Differences in median biomarker concentrations between groups, and associations with the free androgen index (FAI; Testosterone/SHBG x100).

Results

The cluster analysis identified leptin, RBP-4, DPP-IV and adiponectin as potential discriminative markers for HA-PCOS with a specifically strong correlation in cases with increased BMI. Leptin (R2 = 0.219) and adiponectin (R2 = 0.182) showed the strongest correlation with the FAI. When comparing median protein concentrations adult PCOS women with or without hyperandrogenemia, the most profound differences were observed for leptin (P < 0.001), DPP-IV (P = 0.005), and adiponectin (P < 0.001). Adjusting for age, BMI and multiple testing attenuated all differences. In PCOS offspring, MMP-9 (P = 0.001) and S100A8 (P < 0.001) concentrations were significantly higher compared to a healthy matched reference population, even after correcting for age and BMI and adjustment for multiple testing.

Conclusion

In this preliminary investigation we observed significant differences in adipocytokines between women with or without hyperandrogenic PCOS and non-PCOS controls, mostly influenced by BMI. Leptin and adiponectin showed the strongest correlation with the FAI in adult women with PCOS. In PCOS offspring other inflammatory biomarkers (MMP-9, S100A8) were increased, suggesting that these children may exhibit increased chronic low-grade inflammation. Additional research is required to confirm results of the current exploratory investigation.

SUBMITTER: Daan NM 

PROVIDER: S-EPMC5091782 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Biomarker Profiles in Women with PCOS and PCOS Offspring; A Pilot Study.

Daan Nadine M P NM   Koster Maria P H MP   de Wilde Marlieke A MA   Dalmeijer Gerdien W GW   Evelein Annemieke M V AM   Fauser Bart C J M BC   de Jager Wilco W  

PloS one 20161102 11


<h4>Objective</h4>To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring.<h4>Design</h4>Cross-sectional comparison of serum biomarkers.<h4>Setting</h4>University Medical Center Utrecht.<h4>Patients</h4>Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30).<h4>Main outcome measure(s)</h4>Clusteri  ...[more]

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