Ontology highlight
ABSTRACT:
SUBMITTER: Natisvili T
PROVIDER: S-EPMC5091837 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Natisvili Theona T Yandim Cihangir C Silva Raquel R Emanuelli Giulia G Krueger Felix F Nageshwaran Sathiji S Festenstein Richard R
PloS one 20161102 11
Heterochromatinisation of pericentromeres, which in mice consist of arrays of major satellite repeats, are important for centromere formation and maintenance of genome stability. The dysregulation of this process has been linked to genomic stress and various cancers. Here we show in mice that the proteasome binds to major satellite repeats and proteasome inhibition by MG132 results in their transcriptional de-repression; this de-repression is independent of cell-cycle perturbation. The transcrip ...[more]