Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
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ABSTRACT:
SUBMITTER: Qiu J
PROVIDER: S-EPMC5092045 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Publications
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
Qiu Jing J McQueen Jamie J Bilican Bilada B Dando Owen O Magnani Dario D Punovuori Karolina K Selvaraj Bhuvaneish T BT Livesey Matthew M Haghi Ghazal G Heron Samuel S Burr Karen K Patani Rickie R Rajan Rinku R Sheppard Olivia O Kind Peter C PC Simpson T Ian TI Tybulewicz Victor Lj VL Wyllie David Ja DJ Fisher Elizabeth Mc EM Lowell Sally S Chandran Siddharthan S Hardingham Giles E GE
eLife 20161001
Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor. Rodent-based studies show that activity-dependent transcriptional programs mediate myriad functions in neuronal development, but the extent of their conservation in human neurons is unknown. We compared activity-dependent transcriptional responses i ...[more]
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