Facile Preparation of Multifunctional WS₂ /WO_x Nanodots for Chelator-Free ⁸⁹ Zr-Labeling and In Vivo PET Imaging.

ABSTRACT: While position emission tomography (PET) is an important molecular imaging technique for both preclinical research and clinical disease diagnosis/prognosis, chelator-free radiolabeling has emerged as a promising alternative approach to label biomolecules or nanoprobes in a facile way. Herein, starting from bottom-up synthesized WS₂ nanoflakes, this study fabricates a unique type of WS₂ /WO_x nanodots, which can function as inherent hard oxygen donor for stable radiolabeling with Zirconium-89 isotope (⁸⁹ Zr). Upon simply mixing, ⁸⁹ Zr can be anchored on the surface of polyethylene glycol (PEG) modified WS₂ /WO_x (WS₂ /WO_x -PEG) nanodots via a chelator-free method with surprisingly high labeling

SUBMITTER: Cheng L 

PROVIDER: S-EPMC5093087 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature