Ontology highlight
ABSTRACT:
SUBMITTER: Davis FM
PROVIDER: S-EPMC5093309 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Davis Felicity M FM Lloyd-Lewis Bethan B Harris Olivia B OB Kozar Sarah S Winton Douglas J DJ Muresan Leila L Watson Christine J CJ
Nature communications 20161025
The mammary gland undergoes cycles of growth and regeneration throughout reproductive life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate-mapping studies using lineage-specific promoters have provided valuable insights into the mammary epithelial hierarchy, the true differentiation potential of adult MaSCs remains unclear. To address this, herein we utilize a stochastic genetic-labelling strategy to indelibly mark a single cell and its progeny in situ, combined w ...[more]