The role of pericytic laminin in blood brain barrier integrity maintenance.
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ABSTRACT:
SUBMITTER: Gautam J
PROVIDER: S-EPMC5093438 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
The role of pericytic laminin in blood brain barrier integrity maintenance.
Gautam Jyoti J Zhang Xuanming X Yao Yao Y
Scientific reports 20161103
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been shown that laminin α4 (endothelial laminin) regulates vascular integrity at embryonic/neonatal stage, while astrocytic laminin maintains vascular integrity in adulthood. Here, we investigate the function of pericyte-deri ...[more]
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