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Association between autonomic nervous dysfunction and cellular inflammation in end-stage renal disease.


ABSTRACT: Alterations in autonomic nervous function are common in hemodialysis (HD) patients. Sympathetic as well as parasympathetic activation may be associated with immune and inflammatory responses. We intended to confirm a role of autonomous dysregulation for inflammation in HD patients.30 HD patients (including 15 diabetics) and 15 healthy controls were studied for heart rate variability (HRV) using 5 min ECG recordings. Heart rate variability was estimated by time-domain parameters (the standard deviation of the RR intervals (SDNN) and the percentage of pairs of adjacent RR intervals differing by >50 ms (pNN50)) and frequency-domain-analysis (high- and low-frequency variation of RR intervals, HF and LF). Inflammation was detected as serum C-reactive Protein (CRP), IL-6 and circulating monocyte subpopulation numbers. Immune cells were characterized by ACh receptor expression.Patients differed from controls in terms of age (68.0 [14.8] yrs vs. 58.0 [13.0] yrs, p?

SUBMITTER: Seibert E 

PROVIDER: S-EPMC5094069 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Association between autonomic nervous dysfunction and cellular inflammation in end-stage renal disease.

Seibert Eric E   Zohles Kristina K   Ulrich Christof C   Kluttig Alexander A   Nuding Sebastian S   Kors Jan A JA   Swenne Cees A CA   Werdan Karl K   Fiedler Roman R   Girndt Matthias M  

BMC cardiovascular disorders 20161103 1


<h4>Background</h4>Alterations in autonomic nervous function are common in hemodialysis (HD) patients. Sympathetic as well as parasympathetic activation may be associated with immune and inflammatory responses. We intended to confirm a role of autonomous dysregulation for inflammation in HD patients.<h4>Methods</h4>30 HD patients (including 15 diabetics) and 15 healthy controls were studied for heart rate variability (HRV) using 5 min ECG recordings. Heart rate variability was estimated by time-  ...[more]

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