Ontology highlight
ABSTRACT:
SUBMITTER: Allegrezza MJ
PROVIDER: S-EPMC5094194 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Allegrezza Michael J MJ Rutkowski Melanie R MR Stephen Tom L TL Svoronos Nikolaos N Perales-Puchalt Alfredo A Nguyen Jenny M JM Payne Kyle K KK Singhal Sunil S Eruslanov Evgeniy B EB Tchou Julia J Conejo-Garcia Jose R JR
Cancer research 20161101 21
Targeted therapies elicit seemingly paradoxical and poorly understood effects on tumor immunity. Here, we show that the MEK inhibitor trametinib abrogates cytokine-driven expansion of monocytic myeloid-derived suppressor cells (mMDSC) from human or mouse myeloid progenitors. MEK inhibition also reduced the production of the mMDSC chemotactic factor osteopontin by tumor cells. Together, these effects reduced mMDSC accumulation in tumor-bearing hosts, limiting the outgrowth of KRas-driven breast t ...[more]