Dataset Information

Vasectomy and risk of prostate cancer: population based matched cohort study.

ABSTRACT:

Objective

To determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour.

Design

Population based matched cohort study.

Setting

Multiple validated healthcare databases in Ontario, Canada, 1994-2012.

Participants

326?607 men aged 20 to 65 who had undergone vasectomy were identified through physician billing codes and matched 1:1 on age (within two years), year of cohort entry, comorbidity score, and geographical region to men who did not undergo a vasectomy.

Main outcomes measures

The primary outcome was incident prostate cancer. Secondary outcomes were prostate cancer related grade, stage, and mortality.

Results

3462 incident cases of prostate cancer were identified after a median follow-up of 10.9 years: 1843 (53.2%) in the vasectomy group and 1619 (46.8%) in the non-vasectomy group. In unadjusted analysis, vasectomy was associated with a slightly increased risk of incident prostate cancer (hazard ratio 1.13, 95% confidence interval 1.05 to 1.20). After adjustment for measures of health seeking behaviour, however, no association remained (adjusted hazard ratio 1.02, 95% confidence interval 0.95 to 1.09). Moreover, no association was found between vasectomy and high grade prostate cancer (adjusted odds ratio 1.05, 95% confidence interval 0.67 to 1.66), advanced stage prostate cancer (adjusted odds ratio 1.04, 0.81 to 1.34), or mortality (adjusted hazard ratio 1.06, 0.60 to 1.85).

Conclusion

The findings do not support an independent association between vasectomy and prostate cancer.

SUBMITTER: Nayan M

PROVIDER: S-EPMC5094198 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Vasectomy and risk of prostate cancer: population based matched cohort study.

Nayan Madhur M Hamilton Robert J RJ Macdonald Erin M EM Li Qing Q Mamdani Muhammad M MM Earle Craig C CC Kulkarni Girish S GS Jarvi Keith A KA Juurlink David N DN

BMJ (Clinical research ed.) 20161103

<h4>Objective</h4> To determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour.<h4>Design</h4> Population based matched cohort study.<h4>Setting</h4> Multiple validated healthcare databases in Ontario, Canada, 1994-2012.<h4>Participants</h4> 326 607 men aged 20 to 65 who had undergone vasectomy were identified through physician billing codes and matched 1:1 on age (within two years), year of cohort entry, comorbidity score, and geographi ...[more]

PMID: 27811008

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Dataset Information

Vasectomy and risk of prostate cancer: population based matched cohort study.

Objective

Design

Setting

Participants

Main outcomes measures

Results

Conclusion

Publications

Vasectomy and risk of prostate cancer: population based matched cohort study.

Similar Datasets

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