Ontology highlight
ABSTRACT:
SUBMITTER: Hong S
PROVIDER: S-EPMC5094372 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Hong Soyon S Beja-Glasser Victoria F VF Nfonoyim Bianca M BM Frouin Arnaud A Li Shaomin S Ramakrishnan Saranya S Merry Katherine M KM Shi Qiaoqiao Q Rosenthal Arnon A Barres Ben A BA Lemere Cynthia A CA Selkoe Dennis J DJ Stevens Beth B
Science (New York, N.Y.) 20160331 6286
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade, is increased and associated with synapses before overt plaque deposition. Inhibition of C1q, C3, or the microglial complement receptor CR3 reduces the ...[more]