Dataset Information

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium.

ABSTRACT:

Background

Gallbladder cancer is a relatively rare malignancy. The current study aimed to define the incidence and patterns of recurrence following gallbladder cancer resection.

Methods

Using a multi-institutional cohort we identified 217 patient undergoing curative intent surgery for gallbladder cancer. Patterns of recurrence were classified as locoregional and distant recurrence.

Results

At last follow-up, 76 patients (35.0%) had experienced a recurrence (locoregional only, n = 12, 15.8%; distant only, n = 50, 65.8%; locoregional and distant, n = 14, 18.4%). Median time to recurrence was 9.5 months (IQR 4.7-17.6) and was not associated with recurrence site (all p > 0.05). On multivariable analysis, T3 disease (HR = 8.44, p = 0.014), lymphovascular invasion (HR = 4.24, p < 0.001) and residual disease (HR = 2.04, p = 0.042) were associated with an increased risk of recurrence. Patients who recurred demonstrated a worse 1-, 3- and 5-year OS (1-year OS: 91.3% vs. 68.6%, p = 0.001, 3-year OS: 79.3% vs. 28.7%, p < 0.001, and 5-year OS: 75.9% vs. 16.0%, p < 0.001). After adjusting for other risk factors, recurrence was independently associated with a decreased OS (HR = 3.71, p = 0.006). Of note, receipt of adjuvant therapy was associated with improved OS (HR = 0.56, p = 0.027) among those patients who developed a tumor recurrence.

Discussion

Over one-third of patients experienced a recurrence after gallbladder cancer surgery. While chemotherapy did not decrease the rate of recurrence, patients who experienced recurrence after administration of adjuvant treatment faired better than patients who did not receive adjuvant therapy.

SUBMITTER: Margonis GA

PROVIDER: S-EPMC5094487 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium.

Margonis Georgios Antonios GA Gani Faiz F Buettner Stefan S Amini Neda N Sasaki Kazunari K Andreatos Nikolaos N Ethun Cecilia G CG Poultsides George G Tran Thuy T Idrees Kamran K Isom Chelsea A CA Fields Ryan C RC Krasnick Bradley B Weber Sharon M SM Salem Ahmed A Martin Robert C G RC Scoggins Charles C Shen Perry P Mogal Harveshp D HD Schmidt Carl C Beal Eliza E Hatzaras Ioannis I Shenoy Rivfka R Maithel Shishir K SK Pawlik Timothy M TM

HPB : the official journal of the International Hepato Pancreato Biliary Association 20160813 11

<h4>Background</h4>Gallbladder cancer is a relatively rare malignancy. The current study aimed to define the incidence and patterns of recurrence following gallbladder cancer resection.<h4>Methods</h4>Using a multi-institutional cohort we identified 217 patient undergoing curative intent surgery for gallbladder cancer. Patterns of recurrence were classified as locoregional and distant recurrence.<h4>Results</h4>At last follow-up, 76 patients (35.0%) had experienced a recurrence (locoregional onl ...[more]

PMID: 27527802

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Dataset Information

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium.

Background

Methods

Results

Discussion

Publications

Rates and patterns of recurrence after curative intent resection for gallbladder cancer: a multi-institution analysis from the US Extra-hepatic Biliary Malignancy Consortium.

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