The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
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ABSTRACT:
SUBMITTER: Yin H
PROVIDER: S-EPMC5094947 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum.
Yin Heng H Jiang Min M Peng Xi X Cui Hengmin H Zhou Yi Y He Min M Zuo Zhicai Z Ouyang Ping P Fan Junde J Fang Jing J
Oncotarget 20160601 24
Aflatoxin B1 (AFB1) has potent hepatotoxic, carcinogenic, genotoxic, immunotoxic and other adverse effects in human and animals. The aim of this study was to investigate the molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum of broilers. Broilers, as experimental animals, were fed 0.6 mg/kg AFB1 diet for 3 weeks. Our results showed that AFB1 reduced the jejunal villus height, villus height/crypt ratio and caused G2/M cell cycle arrest. The G2/M cell cycle was accompanie ...[more]
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