Ontology highlight
ABSTRACT:
SUBMITTER: Tomasetti M
PROVIDER: S-EPMC5095004 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tomasetti Marco M Monaco Federica F Manzella Nicola N Rohlena Jakub J Rohlenova Katerina K Staffolani Sara S Gaetani Simona S Ciarapica Veronica V Amati Monica M Bracci Massimo M Valentino Matteo M Goodwin Jacob J Nguyen Maria M Truksa Jaroslav J Sobol Margaryta M Hozak Pavel P Dong Lan-Feng LF Santarelli Lory L Neuzil Jiri J
Oncotarget 20160601 24
Autophagy favors both cell survival and cancer suppression, and increasing evidence reveals that microRNAs (MIRs) regulate autophagy. Previously we reported that MIR126 is downregulated in malignant mesothelioma (MM). Therefore, we investigated the role of MIR126 in the regulation of cell metabolism and autophagy in MM models. We report that MIR126 induces autophagic flux in MM cells by downregulating insulin receptor substrate-1 (IRS1) and disrupting the IRS1 signaling pathway. This was specifi ...[more]