Ontology highlight
ABSTRACT:
SUBMITTER: Harrison JS
PROVIDER: S-EPMC5095012 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Harrison Jonathan S JS Wang Xuening X Studzinski George P GP
Oncotarget 20160601 24
Acute Myeloid Leukemia (AML) has grave prognosis due to aggressive nature of the disease, the toxicity of standard treatment, and overall low cure rates. We recently showed that AML cells in established culture treated with Cytarabine (AraC) and a differentiation agent combination show enhancement of AraC cytotoxicity. Here we elucidate molecular changes which underlie this observation with focus on AML blasts in primary culture. The cells were treated with AraC at concentrations achievable in c ...[more]