Ontology highlight
ABSTRACT:
SUBMITTER: Jarde T
PROVIDER: S-EPMC5095178 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161026
The development of in vitro culture systems quantitatively and qualitatively recapitulating normal breast biology is key to the understanding of mammary gland biology. Current three-dimensional mammary culture systems have not demonstrated concurrent proliferation and functional differentiation ex vivo in any system for longer than 2 weeks. Here, we identify conditions including Neuregulin1 and R-spondin 1, allowing maintenance and expansion of mammary organoids for 2.5 months in culture. The or ...[more]