Ontology highlight
ABSTRACT:
SUBMITTER: Matsuo N
PROVIDER: S-EPMC5095551 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Matsuo Norikazu N Azuma Koichi K Sakai Kazuko K Hattori Satoshi S Kawahara Akihiko A Ishii Hidenobu H Tokito Takaaki T Kinoshita Takashi T Yamada Kazuhiko K Nishio Kazuto K Hoshino Tomoaki T
Scientific reports 20161104
The most common event responsible for resistance to first- and second-generation (1st and 2nd) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) is acquisition of T790M mutation. We examined whether T790M is related to clinicopathologic or prognostic factors in patients with relapse of EGFR mutant non-small cell lung cancer (NSCLC) after treatment with 1st or 2nd EGFR-TKIs. We retrospectively reviewed the T790M status and clinical characteristics of 73 patients with advance ...[more]