Ontology highlight
ABSTRACT:
SUBMITTER: Needham SR
PROVIDER: S-EPMC5095584 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Needham Sarah R SR Roberts Selene K SK Arkhipov Anton A Mysore Venkatesh P VP Tynan Christopher J CJ Zanetti-Domingues Laura C LC Kim Eric T ET Losasso Valeria V Korovesis Dimitrios D Hirsch Michael M Rolfe Daniel J DJ Clarke David T DT Winn Martyn D MD Lajevardipour Alireza A Clayton Andrew H A AH Pike Linda J LJ Perani Michela M Parker Peter J PJ Shan Yibing Y Shaw David E DE Martin-Fernandez Marisa L ML
Nature communications 20161031
Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures and functions of the oligomers are poorly understood. Here, we use fluorophore localization imaging with photobleaching to probe the structure of EGFR oligomers. We find that at physiological epidermal growth factor (EGF) concentrations, EGFR assembles into oligomers, as indicated by pairwise distances of receptor-b ...[more]