Ontology highlight
ABSTRACT:
SUBMITTER: Cromm PM
PROVIDER: S-EPMC5096054 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20160906 20
Macrocyclization can be used to constrain peptides in their bioactive conformations, thereby supporting target affinity and bioactivity. In particular, for the targeting of challenging protein-protein interactions, macrocyclic peptides have proven to be very useful. Available approaches focus on the stabilization of α-helices, which limits their general applicability. Here we report for the first time on the use of ring-closing alkyne metathesis for the stabilization of an irregular peptide seco ...[more]