Ontology highlight
ABSTRACT:
SUBMITTER: Shin I
PROVIDER: S-EPMC5096380 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Shin Inji I Hong Suckchang S Krische Michael J MJ
Journal of the American Chemical Society 20161025 43
Diverse hydrogen-mediated C-C couplings enable construction of the actin-binding marine polyketide swinholide A in only 15 steps (longest linear sequence), roughly half the steps required in two prior total syntheses. The redox-economy, chemo- and stereoselectivity embodied by this new class of C-C couplings are shown to evoke a step-change in efficiency. ...[more]