Ontology highlight
ABSTRACT:
SUBMITTER: Mason CC
PROVIDER: S-EPMC5096889 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Mason C C CC Khorashad J S JS Tantravahi S K SK Kelley T W TW Zabriskie M S MS Yan D D Pomicter A D AD Reynolds K R KR Eiring A M AM Kronenberg Z Z Sherman R L RL Tyner J W JW Dalley B K BK Dao K-H KH Yandell M M Druker B J BJ Gotlib J J O'Hare T T Deininger M W MW
Leukemia 20151209 4
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy nearly confined to the elderly. Previous studies to determine incidence and prognostic significance of somatic mutations in CMML have relied on candidate gene sequencing, although an unbiased mutational search has not been conducted. As many of the genes commonly mutated in CMML were recently associated with age-related clonal hematopoiesis (ARCH) and aged hematopoiesis is characterized by a myelomonocytic differentiation bias, w ...[more]