Ontology highlight
ABSTRACT:
SUBMITTER: Bergstrom K
PROVIDER: S-EPMC5097036 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Bergstrom K K Fu J J Johansson M E V ME Liu X X Gao N N Wu Q Q Song J J McDaniel J M JM McGee S S Chen W W Braun J J Hansson G C GC Xia L L
Mucosal immunology 20160504 1
Core 1- and 3-derived mucin-type O-glycans are primary components of the mucus layer in the colon. Reduced mucus thickness and impaired O-glycosylation are observed in human ulcerative colitis. However, how both types of O-glycans maintain mucus barrier function in the colon is unclear. We found that C1galt1 expression, which synthesizes core 1 O-glycans, was detected throughout the colon, whereas C3GnT, which controls core 3 O-glycan formation, was most highly expressed in the proximal colon. C ...[more]