Potential anti-obesity effects of a long-acting cocaine hydrolase.
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ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC5097895 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Potential anti-obesity effects of a long-acting cocaine hydrolase.
Zheng Xirong X Deng Jing J Zhang Ting T Yao Jianzhuang J Zheng Fang F Zhan Chang-Guo CG
Chemico-biological interactions 20160506 Pt B
A long-acting cocaine hydrolase, known as CocH3-Fc(M3), engineered from human butyrylcholinesterase (BChE) was tested, in this study, for its potential anti-obesity effects. Mice on a high-fat diet gained significantly less body weight when treated weekly with 1 mg/kg CocH3-Fc(M3) compared to control mice, though their food intake was similar. There is no correlation between the average body weight and the average food intake, which is consistent with the previously reported observation in BChE ...[more]
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