Ontology highlight
ABSTRACT:
SUBMITTER: Kojima T
PROVIDER: S-EPMC5098219 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20161107
CD200R is an inhibitory receptor expressed on myeloid cells and some lymphoid cells, and plays important roles in negatively regulating immune responses. CD200 is the only known ligand of CD200R and broadly distributed in a variety of cell types. Here we identified novel CD200 homologues, designated iSEC1 and iSEC2, that are expressed exclusively by secretory cell lineages in the gastrointestinal epithelium while authentic CD200 is expressed by none of epithelial cells including secretory cells. ...[more]