Ontology highlight
ABSTRACT:
SUBMITTER: Yin Y
PROVIDER: S-EPMC5098441 | biostudies-literature | 2016 Nov/Dec
REPOSITORIES: biostudies-literature
Yin Yiyuan Y Han Guanghui G Zhou Jianhui J Dillon Michael M McCarty Luke L Gavino Lou L Ellerman Diego D Spiess Christoph C Sandoval Wendy W Carter Paul J PJ
mAbs 20160909 8
Bispecific IgG are heterotetramers comprising 2 pairs of heavy and light chains. Co-expression of the 4 component chains in a single host cell typically yields the desired bispecific IgG plus up to 9 additional incorrect chain pairings. Several protein engineering strategies have been reported to facilitate the heterodimerization of antibody heavy chains or cognate pairing of antibody heavy and light chains. These technologies have been used to direct the efficient assembly of bispecific IgG in ...[more]