Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen QA
PROVIDER: S-EPMC5098909 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Nguyen Quynh-Anh QA Horn Meryl E ME Nicoll Roger A RA
eLife 20161102
Neuroligins (NLGNs) are postsynaptic cell adhesion molecules that interact trans-synaptically with neurexins to mediate synapse development and function. NLGN2 is only at inhibitory synapses while NLGN3 is at both excitatory and inhibitory synapses. We found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. ...[more]