Ontology highlight
ABSTRACT:
SUBMITTER: Dunstan SJ
PROVIDER: S-EPMC5099079 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Dunstan Sarah J SJ Hue Nguyen Thi NT Han Buhm B Li Zheng Z Tram Trinh Thi Bich TT Sim Kar Seng KS Parry Christopher M CM Chinh Nguyen Tran NT Vinh Ha H Lan Nguyen Phu Huong NP Thieu Nga Tran Vu NT Vinh Phat Voong PV Koirala Samir S Dongol Sabina S Arjyal Amit A Karkey Abhilasha A Shilpakar Olita O Dolecek Christiane C Foo Jia Nee JN Phuong Le Thi le T Lanh Mai Ngoc MN Do Tan T Aung Tin T Hon Do Nu DN Teo Yik Ying YY Hibberd Martin L ML Anders Katherine L KL Okada Yukinori Y Raychaudhuri Soumya S Simmons Cameron P CP Baker Stephen S de Bakker Paul I W PI Basnyat Buddha B Hien Tran Tinh TT Farrar Jeremy J JJ Khor Chiea Chuen CC
Nature genetics 20141110 12
Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-D ...[more]