Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease.
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ABSTRACT: Background
The proteasome system is involved in several disorders. The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) -8 C/G, associated with diabetes, myocardial infarction and coronary artery disease.Methods
We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for -8 C/G SNP by polymerase chain reaction and restriction analysis.Results
We observed lower frequency of CG + GG genotypes in patients than in controls (20 vs. 42 %, p = 0.0038). The odds ratio of 0.34 (95 % CI 0.26-0.45) suggests association of CG + GG with decreased risk of ESKD. We investigated the association between PSMA6 polymorphism and LVH present in 54 % of patients. There was a significant association of CG + GG genotype with LVH, with over 75 % of CG + GG in patients with LVH. This effect was independent from other common causes of LVH-age (OR 1.12, p = 0.643) and hypertension (OR 1.72, p = 0.422).Conclusion
We demonstrated for the first time that PSMA6 polymorphism might be a protective factor for ESKD. On the other hand, CG + GG genotypes are independently related to LVH in ESKD patients.
SUBMITTER: Buraczynska M
PROVIDER: S-EPMC5099367 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Association between functional variant of inflammatory system gene (PSMA6) and end-stage kidney disease.
Buraczynska Monika M Stec Anna A Filipczak Aleksandra A Ksiazek Andrzej A
International urology and nephrology 20160926 12
<h4>Background</h4>The proteasome system is involved in several disorders. The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism (SNP) -8 C/G, associated with diabetes, myocardial infarction and coronary artery disease.<h4>Methods</h4>We examined 584 patients with end-stage kidney disease (ESKD) and 430 controls. All were genotyped for -8 C/G SNP by polymerase chain reaction and restriction analysis.<h4>Results</h4>We observed lower frequency of CG + GG genotypes in ...[more]
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