Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC5099753 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Li Chenxi C Bai Xiaofei X Meng Runze R Shaozhou Wulin W Zhang Qingshan Q Hua Ronghong R Liu Jyung-Hurng JH Liu Ming M Zhang Yun Y
Scientific reports 20161108
In 2010, a pathogenic flavivirus termed duck Tembusu virus (DTMUV) caused widespread outbreak of egg-drop syndrome in domesticated ducks in China. Although the glycoprotein E of DTMUV is an important structural component of the virus, the B-cell epitopes of this protein remains uncharacterized. Using phage display and mutagenesis, we identified a minimal B-cell epitope, <sup>374</sup>EXE/DPPFG<sup>380</sup>, that mediates binding to a nonneutralizing monoclonal antibody. DTMUV-positive duck seru ...[more]