Ontology highlight
ABSTRACT:
SUBMITTER: Kumar V
PROVIDER: S-EPMC5099936 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kumar Vinod V Sanseau Philippe P Simola Daniel F DF Hurle Mark R MR Agarwal Pankaj P
Scientific reports 20161108
It is commonly assumed that drug targets are expressed in tissues relevant to their indicated diseases, even under normal conditions. While multiple anecdotal cases support this hypothesis, a comprehensive study has not been performed to verify it. We conducted a systematic analysis to assess gene and protein expression for all targets of marketed and phase III drugs across a diverse collection of normal human tissues. For 87% of gene-disease pairs, the target is expressed in a disease-affected ...[more]