The network sustaining action myoclonus: a MEG-EMG study in patients with EPM1.

ABSTRACT:

Background

To explore the cortical network sustaining action myoclonus and to found markers of the resulting functional impairment, we evaluated the distribution of the cortico-muscular coherence (CMC) and the frequency of coherent cortical oscillations with magnetoencephalography (MEG). All patients had EPM1 (Unverricht-Lundborg) disease known to present with prominent and disabling movement-activated myoclonus.

Methods

Using autoregressive models, we evaluated CMC on MEG sensors grouped in regions of interests (ROIs) above the main cortical areas. The movement was a repeated sustained isometric extension of the right hand and right foot. We compared the data obtained in 10 EPM1 patients with those obtained in 10 age-matched controls.

Results

As expected, CMC in beta

SUBMITTER: Franceschetti S 

PROVIDER: S-EPMC5100097 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature