Mechanistic insights into mammalian stress granule dynamics.
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ABSTRACT:
SUBMITTER: Panas MD
PROVIDER: S-EPMC5100297 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Mechanistic insights into mammalian stress granule dynamics.
Panas Marc D MD Ivanov Pavel P Anderson Paul P
The Journal of cell biology 20161101 3
The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related domains and intrinsically disordered protein regions found in SG-nucleating proteins promote the condensation of ribonucleoproteins into SGs. We propose that PIC components, especially 40S ribosomes and mRNA, recruit nucleators that trigger SG condensation. With resolution of stress, translation reinitiation reverses this process and SGs di ...[more]
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