Ontology highlight
ABSTRACT:
SUBMITTER: Kar A
PROVIDER: S-EPMC5100571 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Kar Anirban A Willcox Smaranda S Griffith Jack D JD
Nucleic acids research 20160907 19
The formation of DNA loops at chromosome ends (t-loops) and the transcription of telomeres producing G-rich RNA (TERRA) represent two central features of telomeres. To explore a possible link between them we employed artificial human telomeres containing long arrays of TTAGGG repeats flanked by the T7 or T3 promoters. Transcription of these DNAs generates a high frequency of t-loops within individual molecules and homologous recombination events between different DNAs at their telomeric sequence ...[more]