Dataset Information

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.

ABSTRACT:

Background

Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.

Methods

A comprehensive molecular profile (75 metabolic measures and 37 cytokines) was measured for up to 5841 women (age range 24-49 years) from three population-based cohorts. Women using combined oral contraceptive pills (COCPs) or progestin-only contraceptives (POCs) were compared with those who did not use hormonal contraception. Metabolomics profiles were reassessed for 869 women after 6 years to uncover the metabolic effects of starting, stopping and persistently using hormonal contraception.

Results

The comprehensive molecular profiling allowed multiple new findings on the metabolic associations with the use of COCPs. They were positively associated with lipoprotein subclasses, including all high-density lipoprotein (HDL) subclasses. The associations with fatty acids and amino acids were strong and variable in direction. COCP use was negatively associated with albumin and positively associated with creatinine and inflammatory markers, including glycoprotein acetyls and several growth factors and interleukins. Our findings also confirmed previous results e.g. for increased circulating triglycerides and HDL cholesterol. Starting COCPs caused similar metabolic changes to those observed cross-sectionally: the changes were maintained in consistent users and normalized in those who stopped using. In contrast, POCs were only weakly associated with metabolic and inflammatory markers. Results were consistent across all cohorts and for different COCP preparations and different types of POC delivery.

Conclusions

Use of COCPs causes widespread metabolic and inflammatory effects. However, persistent use does not appear to accumulate the effects over time and the metabolic perturbations are reversed upon discontinuation. POCs have little effect on systemic metabolism and inflammation.

SUBMITTER: Wang Q

PROVIDER: S-EPMC5100613 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.

Wang Qin Q Würtz Peter P Auro Kirsi K Morin-Papunen Laure L Kangas Antti J AJ Soininen Pasi P Tiainen Mika M Tynkkynen Tuulia T Joensuu Anni A Havulinna Aki S AS Aalto Kristiina K Salmi Marko M Blankenberg Stefan S Zeller Tanja T Viikari Jorma J Kähönen Mika M Lehtimäki Terho T Salomaa Veikko V Jalkanen Sirpa S Järvelin Marjo-Riitta MR Perola Markus M Raitakari Olli T OT Lawlor Debbie A DA Kettunen Johannes J Ala-Korpela Mika M

International journal of epidemiology 20160818 5

<h4>Background</h4>Hormonal contraception is commonly used worldwide, but its systemic effects across lipoprotein subclasses, fatty acids, circulating metabolites and cytokines remain poorly understood.<h4>Methods</h4>A comprehensive molecular profile (75 metabolic measures and 37 cytokines) was measured for up to 5841 women (age range 24-49 years) from three population-based cohorts. Women using combined oral contraceptive pills (COCPs) or progestin-only contraceptives (POCs) were compared with ...[more]

PMID: 27538888

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Dataset Information

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.

Background

Methods

Results

Conclusions

Publications

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.

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