Ontology highlight
ABSTRACT:
SUBMITTER: Lee N
PROVIDER: S-EPMC5100879 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lee Namgyu N Ryu Hye Guk HG Kwon Jung-Hee JH Kim Dae-Kyum DK Kim Sae Rom SR Wang Hee Jung HJ Kim Kyong-Tai KT Choi Kwan Yong KY
PloS one 20161108 11
The role of Sirtuin 6 (SIRT6) as a tumor suppressor or oncogene in liver cancer remains controversial. Thus, we identified the specific role of SIRT6 in the progression of hepatocellular carcinoma (HCC). SIRT6 expression was significantly higher in HCC cell lines and HCC tissues from 138 patients than in an immortalized hepatocyte cell line, THLE-2 and non-tumor tissues, respectively. SIRT6 knockdown by shRNA suppressed the growth of HCC cells and inhibited HCC tumor growth in vivo. In addition, ...[more]