Ontology highlight
ABSTRACT:
SUBMITTER: Christensen AP
PROVIDER: S-EPMC5100928 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Christensen Adam P AP Akyuz Nurunisa N Corey David P DP
PloS one 20161108 11
TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic pharmaceuticals such as channel blockers. Recently, the structure of TRPA1 was reported, providing insights into channel assembly and pore architecture. Here we report whole-cell and single-channel current recordings of wild-type human TRPA1 as well as TRPA1 bearing point mut ...[more]