Ontology highlight
ABSTRACT:
SUBMITTER: Hakim FT
PROVIDER: S-EPMC5101132 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20160930 9
Although chronic graft-versus-host disease (CGVHD) is the primary nonrelapse complication of allogeneic transplantation, understanding of its pathogenesis is limited. To identify the main operant pathways across the spectrum of CGVHD, we analyzed gene expression in circulating monocytes, chosen as in situ systemic reporter cells. Microarrays identified two interrelated pathways: 1) IFN-inducible genes, and 2) innate receptors for cellular damage. Corroborating these with multiplex RNA quantitati ...[more]