Ontology highlight
ABSTRACT:
SUBMITTER: Aydemir TB
PROVIDER: S-EPMC5101137 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Aydemir Tolunay Beker TB Troche Catalina C Kim Jinhee J Kim Min-Hyun MH Teran Oriana Y OY Leeuwenburgh Christiaan C Cousins Robert J RJ
Experimental gerontology 20160916
Inflammation and zinc dyshomeostasis are two common hallmarks of aging. A major zinc transporter ZIP14 (slc39a14) is upregulated by proinflammatory stimuli, e.g. interleukin-6. We have evaluated the influence of age on the Zip14 KO phenotype using wild-type (WT) and Zip14 knockout (KO) mice. Aging produced a major increase in serum IL-6 concentrations that was dramatically augmented in the Zip14 KO mice. In keeping with enhanced serum IL-6 concentrations, aging produced tissue-specific increases ...[more]