Ontology highlight
ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC5101446 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Lee Wonyong W Kim Hyeong Su HS Baek Song Yi SY Lee Gap Ryol GR
Cellular & molecular immunology 20150713 6
Recent studies have suggested that regulatory T (Treg) cells comprise a heterogeneous population that regulates various aspects of the immune response, and that Treg cells use the factors that are expressed in their target cells to regulate them. We searched for factors that regulate Th1 response in Treg cells using a meta-analysis. In the process, we discovered that transcription factor interferon regulatory factor 8 (IRF8) was selectively expressed in Treg and Th1 cells. IRF8-deficient Treg ce ...[more]