Ontology highlight
ABSTRACT:
SUBMITTER: Ochel A
PROVIDER: S-EPMC5101449 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Ochel Aaron A Cebula Marcin M Riehn Mathias M Hillebrand Upneet U Lipps Christoph C Schirmbeck Reinhold R Hauser Hansjörg H Wirth Dagmar D
Cellular & molecular immunology 20151012 6
Liver infections with hepatotropic viruses, such as hepatitis B virus and hepatitis C virus are accompanied by viral persistence and immune failure. CD8+ T cells are crucial mediators of the intrahepatic antiviral immune response. Chronic infections of the liver and other organs correlate with T-cell exhaustion. It was previously suggested that high antigen load could result in T-cell exhaustion. We aimed at elucidating the impact of different intrahepatic antigen loads on the quality of CD8+ T- ...[more]