Ontology highlight
ABSTRACT:
SUBMITTER: Gohain N
PROVIDER: S-EPMC5101508 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Gohain Neelakshi N Tolbert William D WD Orlandi Chiara C Richard Jonathan J Ding Shilei S Chen Xishan X Bonsor Daniel A DA Sundberg Eric J EJ Lu Wuyuan W Ray Krishanu K Finzi Andrés A Lewis George K GK Pazgier Marzena M
Scientific reports 20161109
Antibody-dependent cell-mediated cytotoxicity (ADCC) by non-neutralizing antibodies (nnAbs) specific to the HIV envelope (Env) glycoproteins present at the surface of virus sensitized or infected cells plays a role in the effective adaptive immune response to HIV. Here, we explore the molecular basis for the epitope at the disulfide loop region (DLR) of the principal immunodominant domain of gp41, recognized by the well-known nnAb F240. Our structural studies reveal details of the F240-gp41 inte ...[more]