Effect of adding intrathecal morphine to a multimodal analgesic regimen for postoperative pain management after laparoscopic bariatric surgery: a prospective, double-blind, randomized controlled trial.

ABSTRACT: BACKGROUND:Pain control after bariatric surgery is a major challenge. Our objective was to study the efficacy and safety of intrathecal (IT) morphine 0.3?mg added to bupivacaine 0.5% for postoperative pain after laparoscopic bariatric surgery. METHODS:After local ethics committee approval, 100 morbidly obese patients scheduled for laparoscopic bariatric surgery were enrolled in this study. Patients were randomly assigned into two groups: Group I received IT 0.3?mg morphine (0.3?mL) added to 1.2?mL of bupivacaine 0.5%; Group II received IT 0.3?mL saline added to 1.2?mL of bupivacaine 0.5%, immediately before induction of general anaesthesia. For both groups, 60?mg ketorolac and 1000?mg paracetamol were infused 30?minutes before the end of surgery. After wound closure, 20?mL bupivacaine 0.25% was infiltrated at wound edges. RESULTS:Visual Analogue Scale (VAS) score was significantly lower in group I immediately, 30?minutes and 1?hour postoperatively. Time to first ambulation, return of intestinal sounds and hospital stay were shorter in group I than group II (p?

SUBMITTER: El Sherif FA 

PROVIDER: S-EPMC5102100 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature