Ontology highlight
ABSTRACT:
SUBMITTER: Laugeray A
PROVIDER: S-EPMC5102430 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Laugeray Anthony A Launay Jean-Marie JM Callebert Jacques J Mutlu Oguz O Guillemin Gilles J GJ Belzung Catherine C Barone Pascal R PR
PloS one 20161109 11
We demonstrated that confronting mice to the Unpredictable Chronic Mild Stress (UCMS) procedure-a validated model of stress-induced depression-results in behavioural alterations and biochemical changes in the kynurenine pathway (KP), suspected to modify the glutamatergic neurotransmission through the imbalance between downstream metabolites such as 3-hydroxykynurenine, quinolinic and kynurenic acids. We showed that daily treatment with the IDO1 inhibitor 1-methyl-D-tryptophan partially rescues U ...[more]