Ontology highlight
ABSTRACT:
SUBMITTER: Stopfer P
PROVIDER: S-EPMC5102573 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Stopfer P P Giessmann T T Hohl K K Sharma A A Ishiguro N N Taub M E ME Zimdahl-Gelling H H Gansser D D Wein M M Ebner T T Müller F F
Clinical pharmacology and therapeutics 20160729 3
This article reports the clinical investigation of a probe drug cocktail containing substrates of key drug transporters. Single oral doses of 0.25 mg digoxin (P-gp), 5 mg furosemide (OAT1 and OAT3), 500 mg metformin (OCT2, MATE1, and MATE2-K), and 10 mg rosuvastatin (OATP1B1, OATP1B3, and BCRP) were administered separately or as a cocktail in a randomized six-period crossover trial in 24 healthy male volunteers. As a cocktail, relative bioavailabilities of digoxin and metformin and furosemide AU ...[more]