Dataset Information

Age-related differences in brain network activation and co-activation during multiple object tracking.

ABSTRACT:

Introduction

Multiple object tracking (MOT) is a powerful paradigm for measuring sustained attention. Although previous fMRI studies have delineated the brain activation patterns associated with tracking and documented reduced tracking performance in aging, age-related effects on brain activation during MOT have not been characterized. In particular, it is unclear if the task-related activation of different brain networks is correlated, and also if this coordination between activations within brain networks shows differential effects of age.

Methods

We obtained fMRI data during MOT at two load conditions from a group of younger (n = 25, mean age = 24.4 ± 5.1 years) and older (n = 21, mean age = 64.7 ± 7.4 years) healthy adults. Using a combination of voxel-wise and independent component analysis, we investigated age-related differences in the brain network activation. In order to explore to which degree activation of the various brain networks reflect unique and common mechanisms, we assessed the correlations between the brain networks' activations.

Results

Behavioral performance revealed an age-related reduction in MOT accuracy. Voxel and brain network level analyses converged on decreased load-dependent activations of the dorsal attention network (DAN) and decreased load-dependent deactivations of the default mode networks (DMN) in the old group. Lastly, we found stronger correlations in the task-related activations within DAN and within DMN components for younger adults, and stronger correlations between DAN and DMN components for older adults.

Conclusion

Using MOT as means for measuring attentional performance, we have demonstrated an age-related attentional decline. Network-level analysis revealed age-related alterations in network recruitment consisting of diminished activations of DAN and diminished deactivations of DMN in older relative to younger adults. We found stronger correlations within DMN and within DAN components for younger adults and stronger correlations between DAN and DMN components for older adults, indicating age-related alterations in the coordinated network-level activation during attentional processing.

SUBMITTER: Dorum ES

PROVIDER: S-EPMC5102637 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Publications

Age-related differences in brain network activation and co-activation during multiple object tracking.

Dørum Erlend S ES Alnæs Dag D Kaufmann Tobias T Richard Geneviève G Lund Martina J MJ Tønnesen Siren S Sneve Markus H MH Mathiesen Nina C NC Rustan Øyvind G ØG Gjertsen Øivind Ø Vatn Sigurd S Fure Brynjar B Andreassen Ole A OA Nordvik Jan Egil JE Westlye Lars T LT

Brain and behavior 20160907 11

<h4>Introduction</h4>Multiple object tracking (MOT) is a powerful paradigm for measuring sustained attention. Although previous fMRI studies have delineated the brain activation patterns associated with tracking and documented reduced tracking performance in aging, age-related effects on brain activation during MOT have not been characterized. In particular, it is unclear if the task-related activation of different brain networks is correlated, and also if this coordination between activations w ...[more]

PMID: 27843692

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Dataset Information

Age-related differences in brain network activation and co-activation during multiple object tracking.

Introduction

Methods

Results

Conclusion

Publications

Age-related differences in brain network activation and co-activation during multiple object tracking.

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