An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy.
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ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5103075 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy.
Chen Yichao Y Xia Rui R Huang Yixian Y Zhao Wenchen W Li Jiang J Zhang Xiaolan X Wang Pengcheng P Venkataramanan Raman R Fan Jie J Xie Wen W Ma Xiaochao X Lu Binfeng B Li Song S
Nature communications 20161107
Immunochemotherapy combines a chemotherapeutic agent with an immune-modulating agent and represents an attractive approach to improve cancer therapy. However, the success of immunochemotherapy is hampered by the lack of a strategy to effectively co-deliver the two therapeutics to the tumours. Here we report the development of a dual-functional, immunostimulatory nanomicellar carrier that is based on a prodrug conjugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently ...[more]
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