Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC5103210 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Xu Hui H Li Zhongyu Z Yu Yue Y Sizdahkhani Saman S Ho Winson S WS Yin Fangchao F Wang Li L Zhu Guoli G Zhang Min M Jiang Lei L Zhuang Zhengping Z Qin Jianhua J
Scientific reports 20161110
The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases. We proposed a new and dynamic in vivo-like three-dimensional microfluidic system that replicates the key structural, functional and mechanical properties of the blood-brain barrier in vivo. Multiple factors in this system work synergistically to accentuate BBB-specific attributes-permitting the analysis of complex organ-level responses in b ...[more]