Ontology highlight
ABSTRACT:
SUBMITTER: Machovina TS
PROVIDER: S-EPMC5104180 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Machovina Tyler S TS Mainpal Rana R Daryabeigi Anahita A McGovern Olivia O Paouneskou Dimitra D Labella Sara S Zetka Monique M Jantsch Verena V Yanowitz Judith L JL
Current biology : CB 20161006 21
Crossover (CO) recombination creates a physical connection between homologs that promotes their proper segregation at meiosis I (MI). Failure to realize an obligate CO causes homologs to attach independently to the MI spindle and separate randomly, leading to nondisjunction. However, mechanisms that determine whether homolog pairs have received crossovers remain mysterious. Here we describe a surveillance system in C. elegans that monitors recombination intermediates and couples their formation ...[more]