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Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing.

ABSTRACT: Silk fibers spun by silkworms and spiders exhibit exceptional mechanical properties with a unique combination of strength, extensibility and toughness. In contrast, the mechanical properties of regenerated silk materials can be tuned through control of the fabrication process. Here we introduce a biomimetic, all-aqueous process, to obtain bulk regenerated silk-based materials for the fabrication of functionalized orthopedic devices. The silk materials generated in the process replicate the nano-scale structure of natural silk fibers and possess excellent mechanical properties. The biomimetic materials demonstrate excellent machinability, providing a path towards the fabrication of a new family of resorbable orthopedic devices where organic solvents are avoided, thus allowing functionalization with bioactive molecules to promote bone remodeling and integration.

SUBMITTER: Li C

PROVIDER: S-EPMC5104183 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing.

Li Chunmei C Hotz Blake B Ling Shengjie S Guo Jin J Haas Dylan S DS Marelli Benedetto B Omenetto Fiorenzo F Lin Samuel J SJ Kaplan David L DL

Biomaterials 20160920

Silk fibers spun by silkworms and spiders exhibit exceptional mechanical properties with a unique combination of strength, extensibility and toughness. In contrast, the mechanical properties of regenerated silk materials can be tuned through control of the fabrication process. Here we introduce a biomimetic, all-aqueous process, to obtain bulk regenerated silk-based materials for the fabrication of functionalized orthopedic devices. The silk materials generated in the process replicate the nano- ...[more]

PMID: 27697669

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