Dataset Information

Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

ABSTRACT:

Objective

Although blood-brain barrier (BBB) impairment has been reported in HIV-infected individuals, characterization of this impairment has not been clearly defined.

Methods

BBB integrity was measured by CSF/plasma albumin ratio in this cross-sectional study of 631 HIV-infected individuals and 71 controls. We also analyzed CSF and blood HIV RNA and neopterin, CSF leukocyte count, and neurofilament light chain protein (NFL) concentrations. The HIV-infected participants included untreated neuroasymptomatic patients, patients with untreated HIV-associated dementia (HAD), and participants on suppressive antiretroviral treatment (ART).

Results

The albumin ratio was significantly increased in patients with HAD compared to all other groups. There were no significant differences between untreated neuroasymptomatic participants, treated participants, and controls. BBB integrity, however, correlated significantly with CSF leukocyte count, CSF HIV RNA, serum and CSF neopterin, and age in untreated neuroasymptomatic participants. In a multiple linear regression analysis, age, CSF neopterin, and CSF leukocyte count stood out as independent predictors of albumin ratio. A significant correlation was found between albumin ratio and CSF NFL in untreated neuroasymptomatic patients and in participants on ART. Albumin ratio, age, and CD4 cell count were confirmed as independent predictors of CSF NFL in multivariable analysis.

Conclusions

BBB disruption was mainly found in patients with HAD, where BBB damage correlated with CNS immunoactivation. Albumin ratios also correlated with CSF inflammatory markers and NFL in untreated neuroasymptomatic participants. These findings give support to the association among BBB deterioration, intrathecal immunoactivation, and neuronal injury in untreated neuroasymptomatic HIV-infected individuals.

SUBMITTER: Anesten B

PROVIDER: S-EPMC5104266 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Publications

Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

Anesten Birgitta B Yilmaz Aylin A Hagberg Lars L Zetterberg Henrik H Nilsson Staffan S Brew Bruce J BJ Fuchs Dietmar D Price Richard W RW Gisslén Magnus M

Neurology(R) neuroimmunology & neuroinflammation 20161109 6

<h4>Objective</h4>Although blood-brain barrier (BBB) impairment has been reported in HIV-infected individuals, characterization of this impairment has not been clearly defined.<h4>Methods</h4>BBB integrity was measured by CSF/plasma albumin ratio in this cross-sectional study of 631 HIV-infected individuals and 71 controls. We also analyzed CSF and blood HIV RNA and neopterin, CSF leukocyte count, and neurofilament light chain protein (NFL) concentrations. The HIV-infected participants included ...[more]

PMID: 27868081

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Dataset Information

Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

Objective

Methods

Results

Conclusions

Publications

Blood-brain barrier integrity, intrathecal immunoactivation, and neuronal injury in HIV.

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