Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis.
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ABSTRACT:
SUBMITTER: Nilsonne G
PROVIDER: S-EPMC5104468 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Diurnal Variation of Circulating Interleukin-6 in Humans: A Meta-Analysis.
Nilsonne Gustav G Lekander Mats M Åkerstedt Torbjörn T Axelsson John J Ingre Michael M
PloS one 20161110 11
The pleiotropic cytokine interleukin-6 (IL-6) has been proposed to contribute to circadian regulation of sleepiness by increasing in the blood at night. Earlier studies have reported diurnal variation of IL-6, but phase estimates are conflicting. We have therefore performed a meta-analysis on the diurnal variation of circulating IL-6. Studies were included if they reported IL-6 in plasma or serum recorded at least twice within 24 hours in the same individual. A systematic search resulted in the ...[more]
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